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Article

Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors.

Gene therapy - 1 May 2012

Iyer S, Xiao E, Alsayegh K, Eroshenko N, Riggs M J, Bennett J P, Rao R R

Abstract excerpt

Human pluripotent stem cell-derived neural progenitor (hNP) cells are an excellent resource for understanding early neural development and neurodegenerative disorders. Given that many neurodegenerative disorders can be correlated with defects in the mitochondrial genome, optimal utilization of hNP cells requires an ability to manipulate and monitor changes in the mitochondria. Here, we describe a novel approach...

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Identifiers

PMID: 21918550
DOI: 10.1038/gt.2011.134
PMCID: PMC11071659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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