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Aberrant autophagy and skewed inflammatory and tolerogenic functions in STAT1 gain-of-function dendritic cells

2022-06-27

Abstract excerpt

Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations underlie an inborn error of immunity called chronic mucocutaneous candidiasis. Beyond the fungal susceptibility, attributed to Th17 failure, over half of the reported patients suffer from autoimmune manifestations, the mechanism of which has not been explained yet. Dendritic cells (DCs) have been implicated in the pathogene...

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Literature Corpus work
769aebd6-b9fe-5eec-9de9-f399e18ee343
DOI
10.22541/au.165629547.71126020/v1
Open publication

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Aberrant autophagy and skewed inflammatory and tolerogenic functions in STAT1 gain-of-function dendritic cellsDOI 10.22541/au.165629547.71126020/v1
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