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Article

Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.

Journal of virology - 1 Nov 2011

Alam S Munir, Liao Hua-Xin, Dennison S Moses, Jaeger Frederick, Parks Robert, Anasti Kara, Foulger Andrew, Donathan Michele, Lucas Judith, Verkoczy Laurent, Nicely Nathan, Tomaras Georgia D, Kelsoe Garnett, Chen Bing, Kepler Thomas B, Haynes Barton F

Abstract excerpt

Genetic factors, as well as antigenic stimuli, can influence antibody repertoire formation. Moreover, the affinity of antigen for unmutated naïve B cell receptors determines the threshold for activation of germinal center antibody responses. The gp41 2F5 broadly neutralizing antibody (bNAb) uses the V(H)2-5 gene, which has 10 distinct alleles that use either a heavy-chain complementarity-determining region 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21917975
DOI: 10.1128/JVI.05680-11
PMCID: PMC3209283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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