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Article

Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Scharf Louise, West Anthony P, Gao Han, Lee Terri, Scheid Johannes F, Nussenzweig Michel C, Bjorkman Pamela J, Diskin Ron

Abstract excerpt

Efforts to design an effective antibody-based vaccine against HIV-1 would benefit from understanding how germ-line B-cell receptors (BCRs) recognize the HIV-1 gp120/gp41 envelope spike. Potent VRC01-like (PVL) HIV-1 antibodies derived from the VH1-2*02 germ-line allele target the conserved CD4 binding site on gp120. A bottleneck for design of immunogens capable of eliciting PVL antibodies is that VH1-2*02...

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Share to Antibodies, Neutralizing
Share to Binding Sites, Antibody

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to Immunoglobulin Fragments

Share to Immunoglobulin G

Share to Receptors, Antigen, B-Cell

Share to Surface Plasmon Resonance

Source

Open in PubMed Open full text

Identifiers

PMID: 23524883
DOI: 10.1073/pnas.1303682110
PMCID: PMC3625305

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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