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Article

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

6 Nov 2009

Abstract excerpt

Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 envelope glycoprotein (Env) has not been successful. B12 is highly divergent from the closest...

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PMID: 21994570
DOI: 10.3390/v1030802

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