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Article

Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach

2 Apr 2019

Abstract excerpt

This work reports a universal influenza B virus vaccination strategy based on focusing antibody responses to conserved head and stalk epitopes of the hemagglutinin. Recombinant mosaic influenza B hemagglutinin proteins and recombinant viruses have been generated as novel vaccine candidates. This vaccine strategy provided broad cross-protection in the mouse model. Our findings will inform and drive development...

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PMID: 30944178
DOI: 10.1128/jvi.00333-19

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