Article
Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association study.
Cytokine - 1 Dec 2011
Gallone Salvatore, Di Stefano Marco, Fenoglio Pierpaola, Rubino Elisa, Criasia Antonio, Pinessi Lorenzo, Isaia Giancarlo, Rainero Innocenzo
Abstract excerpt
BACKGROUND: Recent studies suggested that proinflammatory cytokines are involved in the pathophysiology of Paget's disease of bone (PDB). The purpose of this study was to evaluate whether functionally active polymorphisms of the interleukin-1α (IL-1α), interleukin-1β (IL-β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) genes would modify the occurrence and the clinical features of PDB. METHODS:...
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