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Article

Bone density phenotypes in mice aneuploid for the Down syndrome critical region.

American journal of medical genetics. Part A - 1 Oct 2011

Olson Lisa E, Mohan Subburaman

Abstract excerpt

Down syndrome (trisomy 21) is associated with reduced bone density in humans, but it is unclear whether this is due to specific effects of chromosome 21 genes or lifestyle factors. Mouse models with aneuploidy of segments of mouse chromosome 16 that are homologous to human chromosome 21 can be used to elucidate the mechanism by which Down syndrome phenotypes arise. Ts1Rhr and Ms1Rhr mice are trisomic and...

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Identifiers

PMID: 21915988
DOI: 10.1002/ajmg.a.34203
PMCID: PMC13015259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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