Article
Genetic association studies in drug-induced liver injury.
Drug metabolism reviews - 1 Feb 2012
Daly Ann K, Day Christopher P
Abstract excerpt
A large number of case-control association studies on genetic susceptibility to drug-induced liver injury, involving both candidate gene and genome-wide association approaches, have now been reported. The strongest associations have been observed for human leukocyte antigen (HLA) class I and II genes and N-acetyltransferase 2 (NAT2). The associations with HLA class I and II genes are drug specific, though some...
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