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Reactive Oxygen Species, Metabolic Plasticity, and Drug Resistance in Cancer

12 May 2020

Abstract excerpt

The metabolic abnormality observed in tumors is characterized by the dependence of cancer cells on glycolysis for their energy requirements. Cancer cells also exhibit a high level of reactive oxygen species (ROS), largely due to the alteration of cellular bioenergetics. A highly coordinated interplay between tumor energetics and ROS generates a powerful phenotype that provides the tumor cells with proliferative,...

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PMID: 32408513
DOI: 10.3390/ijms21103412

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