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Article

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.

PloS one - 1 Jan 2011

Skalsky Rebecca L, Cullen Bryan R

Abstract excerpt

Glioblastoma is a highly aggressive malignant tumor involving glial cells in the human brain. We used high-throughput sequencing to comprehensively profile the small RNAs expressed in glioblastoma and non-tumor brain tissues. MicroRNAs (miRNAs) made up the large majority of small RNAs, and we identified over 400 different cellular pre-miRNAs. No known viral miRNAs were detected in any of the samples analyzed....

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Identifiers

PMID: 21912681
DOI: 10.1371/journal.pone.0024248
PMCID: PMC3166303

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Source receipt: pubmed, retrieved 7 Sept 2026.

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