Article
KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.
PloS one - 1 Jan 2011
Hanvesakul Raj, Kubal Chandrashekhar, Moore Jason, Neil Desley, Cook Mark, Ball Simon, Briggs David, Moss Paul, Cockwell Paul
Abstract excerpt
BACKGROUND: HLA-C is an important ligand for killer immunoglobulin like receptors (KIR) that regulate natural killer (NK) cell function. Based on KIR specificity HLA-C molecules are allocated into two groups, HLA-C1 or HLA-C2; HLA-C2 is more inhibiting to NK cell function than HLA-C1. We studied the clinical importance of HLA-C genotypes on the long-term graft survival of 760 kidney transplants performed at our...
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