IL‐6, IL‐8, MMP‐2, MMP‐9 are overexpressed in Fanconi anemia cells through a NF‐κB/TNF‐α dependent mechanism

Abstract excerpt

Fanconi anemia (FA) is a rare autosomal recessive genetic disorder associated with a bone-marrow failure, genome instability, hypersensitivity to DNA crosslinking agents and a predisposition to cancer. Mutations have been documented in 16 FA genes that participate in the FA-BRCA DNA repair pathway, a fundamental pathway in the development of the disease and the presentation of its symptoms. FA cells have been...

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