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Article

Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease.

Clinical and experimental immunology - 1 Oct 2011

Horváth R, Rožková D, Lašťovička J, Poloučková A, Sedláček P, Sedivá A, Spíšek R

Abstract excerpt

Hyper-immunoglobulin (Ig)E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD).We...

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Identifiers

PMID: 21910722
DOI: 10.1111/j.1365-2249.2011.04449.x
PMCID: PMC3193916

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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