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Article

Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2016

Becker K L, Rösler B, Wang X, Lachmandas E, Kamsteeg M, Jacobs C W, Joosten L A, Netea M G, van de Veerdonk F L

Abstract excerpt

BACKGROUND: STAT1 mutations cause chronic mucocutaneous candidiasis (CMC), while STAT3 mutations cause hyper-IgE syndrome (HIES). CMC and HIES patients have T helper (Th) 17 defects suffering from mucosal Candida infections, but only patients with HIES show an allergic phenotype with eczema, eosinophilia and high IgE levels. OBJECTIVE: We investigated whether differential Th2 and Th9 responses may explain the...

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Source

Identifiers

PMID: 27474157
DOI: 10.1111/cea.12787

Genes

STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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