Article
Defective trained immunity in patients with STAT-1-dependent chronic mucocutaneaous candidiasis.
Clinical and experimental immunology - 1 Sept 2015
Ifrim D C, Quintin J, Meerstein-Kessel L, Plantinga T S, Joosten L A B, van der Meer J W M, van de Veerdonk F L, Netea M G
Abstract excerpt
Patients with signal transducer and activator of transcription-1 (STAT1)-dependent chronic mucocutaneous candidiasis (CMC) and patients with STAT3-dependent hyper-immunoglobulin (Ig)E syndrome (HIES) display defects in T helper type 17 (Th17) cytokine production capacity. Despite this similar immune defect in Th17 function, they show important differences in the type of infections to which they are susceptible....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.