Article
Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival.
Carcinogenesis - 1 Feb 2013
Garcia-Albeniz Xabier, Nan Hongmei, Valeri Linda, Morikawa Teppei, Kuchiba Aya, Phipps Amanda I, Hutter Carolyn M, Peters Ulrike, Newcomb Polly A, Fuchs Charles S, Giovannucci Edward L, Ogino Shuji, Chan Andrew T
Abstract excerpt
The minor allele (G) of rs4939827, a SMAD7 (18q21) intronic variant, is associated with a lower risk of developing colorectal cancer (CRC) and poorer survival after diagnosis. Our objective was to evaluate the associations of this variant with different tumor phenotype and intratumoral molecular characteristics. We evaluated 1509 CRC cases and 2307 age-matched controls nested within the Nurses' Health Study and...
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