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Article

Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo.

PloS one - 1 Jan 2011

Hafner-Bratkovič Iva, Gaedtke Lars, Ondracka Andrej, Veranič Peter, Vorberg Ina, Jerala Roman

Abstract excerpt

Prion diseases are fatal neurodegenerative diseases, which can be acquired, sporadic or genetic, the latter being linked to mutations in the gene encoding prion protein. We have recently described the importance of subdomain separation in the conversion of prion protein (PrP). The goal of the present study was to investigate the effect of increasing the hydrophobic interactions within the H2-H3 subdomain on PrP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Microscopy, Atomic Force

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Identifiers

PMID: 21909425
DOI: 10.1371/journal.pone.0024238
PMCID: PMC3164720

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