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Article

Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3.

The Journal of biological chemistry - 2 Jul 2010

Adrover Miquel, Pauwels Kris, Prigent Stephanie, de Chiara Cesira, Xu Zhou, Chapuis Céline, Pastore Annalisa, Rezaei Human

Abstract excerpt

Aggregation and misfolding of the prion protein (PrP) are thought to be the cause of a family of lethal neurodegenerative diseases affecting humans and other animals. Although the structures of PrP from several species have been solved, still little is known about the mechanisms that lead to the...

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Identifiers

PMID: 20375014
DOI: 10.1074/jbc.M110.111815
PMCID: PMC2898372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20375014-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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