Article
Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes.
Diabetes - 1 Apr 2021
Haukka Jani, Sandholm Niina, Valo Erkka, Forsblom Carol, Harjutsalo Valma, Cole Joanne B, McGurnaghan Stuart J, Colhoun Helen M, Groop Per-Henrik
Abstract excerpt
Genome-wide association studies (GWAS) and linkage studies have had limited success in identifying genome-wide significantly linked regions or risk loci for diabetic nephropathy (DN) in individuals with type 1 diabetes (T1D). As GWAS cohorts have grown, they have also included more documented and undocumented familial relationships. Here we computationally inferred and manually curated pedigrees in a study cohort...
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