Incidence of Vkorc1 gene mutations in brown rat (Rattus norvegicus) populations from downtown Madrid and their role in resistance to anticoagulant rodenticide: Implications for rodenticide management.

Abstract excerpt

The brown rat (Rattus norvegicus) is considered a pest and the use of anticoagulant rodenticides (ARs) has been considered a valuable method for their management. ARs inhibit the enzyme vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), preventing activation of coagulation factors and provoking death by internal bleeding. Resistance to ARs is associated to Vkorc1 gene mutations. In the present study, we...

Topics

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• Anticoagulants
• Drug Resistance
• VKORC1 gene
• Molecular Docking Simulation
• Mutation