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Article

Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant.

Heart rhythm - 1 Feb 2012

Soucek Radim, Thomas Dierk, Kelemen Kamilla, Bikou Olympia, Seyler Claudia, Voss Frederik, Becker Rüdiger, Koenen Michael, Katus Hugo A, Bauer Alexander

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Gene therapy-dependent modulation of atrial electrophysiology may provide a more specific alternative to pharmacological and ablative treatment strategies. OBJECTIVE: We hypothesized that genetic inactivation of atrial repolarizing ether-a-go-go-related gene (ERG) K(+) currents using a dominant-negative mutant would provide...

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Source

Identifiers

PMID: 21907172
DOI: 10.1016/j.hrthm.2011.09.008

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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