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Article

Selective molecular potassium channel blockade prevents atrial fibrillation.

Circulation - 1 Jun 2010

Amit Guy, Kikuchi Kan, Greener Ian D, Yang Lizhu, Novack Victor, Donahue J Kevin

Abstract excerpt

BACKGROUND: Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that atrial gene transfer would allow focal manipulation of atrial electrophysiology and, by eliminating reentry, would prevent AF. METHODS AND RESULTS: In a porcine AF model, we compared control animals to animals receiving adenovirus that encoded KCNH2-G628S, a dominant negative mutant of the I(Kr)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20479154
DOI: 10.1161/CIRCULATIONAHA.109.911156
PMCID: PMC2892844

Genes

KCNH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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