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Article

Defective DNA double‐strand break repair in pediatric systemic lupus erythematosus

8 Sept 2011

Abstract excerpt

OBJECTIVE: Previous reports of cells from patients with systemic lupus erythematosus (SLE) note that repair of single-strand breaks is delayed, and these lesions may be converted to double-strand breaks (DSBs) at DNA replication forks. We undertook this study to assess the integrity of DSB recognition, signaling, and repair mechanisms in B lymphoblastoid cell lines derived from patients with pediatric SLE....

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Identifiers

PMID: 21905016
DOI: 10.1002/art.33334

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