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Autoantibodies against DNA double-strand break repair proteins

1 Jan 2001

Abstract excerpt

Autoantibodies against cellular components are commonly present in sera from patients with systemic rheumatic diseases and may play an important role in pathogenesis. The Ku protein was recognized 20 years ago as a major target of autoantibodies in a subset of Japanese patients with scleroderma-polymyositis overlap syndrome, and anti-Ku antibodies have since been shown to occur in 10-20% of patients with these...

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PMID: 11689355
DOI: 10.2741/takeda

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