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Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus

8 Aug 2014

Abstract excerpt

INTRODUCTION: Patients with systemic lupus erythematosus (SLE) have an abnormal population of neutrophils, called low-density granulocytes (LDGs), that express the surface markers of mature neutrophils, yet their nuclear morphology resembles an immature cell. Because a similar discrepancy in maturation status is observed in myelodysplasias, and disruption of neutrophil development is frequently associated with...

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PMID: 25107306
DOI: 10.1186/ar4681

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