Article
A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators.
Arthritis and rheumatism - 1 Jan 2012
Broen J C A, Bossini-Castillo L, van Bon L, Vonk M C, Knaapen H, Beretta L, Rueda B, Hesselstrand R, Herrick A, Worthington J, Hunzelman N, Denton C P, Fonseca C, Riemekasten G, Kiener H P, Scorza R, Simeón C P, Ortego-Centeno N, Gonzalez-Gay M A, Airò P, Coenen M J H, Martín J, Radstake T R D J
Abstract excerpt
OBJECTIVE: To investigate whether polymorphisms in Toll-like receptor (TLR) genes, previously reported to be associated with immune-mediated diseases, are involved in systemic sclerosis (SSc). METHODS: We genotyped 14 polymorphisms in the genes for TLRs 2, 4, 7, 8, and 9 in a discovery cohort comprising 452 SSc patients and 537 controls and a replication cohort consisting of 1,170 SSc patients and 925 controls....
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