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Article

Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes.

Mitochondrion - 1 Nov 2011

Francisci Silvia, Montanari Arianna, De Luca Cristina, Frontali Laura

Abstract excerpt

Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects.

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Identifiers

PMID: 21903180
DOI: 10.1016/j.mito.2011.08.006
PMCID: PMC3210327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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