Article
Rare ATAD5 missense variants in breast and ovarian cancer patients.
Cancer letters - 28 Jun 2016
Maleva Kostovska Ivana, Wang Jing, Bogdanova Natalia, Schürmann Peter, Bhuju Sabin, Geffers Robert, Dürst Matthias, Liebrich Clemens, Klapdor Rüdiger, Christiansen Hans, Park-Simon Tjoung-Won, Hillemanns Peter, Plaseska-Karanfilska Dijana, Dörk Thilo
Abstract excerpt
ATAD5/ELG1 is a protein crucially involved in replication and maintenance of genome stability. ATAD5 has recently been identified as a genomic risk locus for both breast and ovarian cancer through genome-wide association studies. We aimed to investigate the spectrum of coding ATAD5 germ-line mutations in hospital-based series of patients with triple-negative breast cancer or serous ovarian cancer compared with...
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