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Article

ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status

12 Dec 2017

Abstract excerpt

BACKGROUND: Aldehyde dehydrogenase (ALDH) has been widely used as a marker of cancer stem cells (CSCs). However, the ALDH family includes 19 members, and the most relevant isoforms and their biological functions in cancer biology are still controversial. METHODS: We examined ALDH enzyme activity and the mRNA expression of 19 ALDH members in 58 human cell lines. The biological effect and mechanism of knocking down...

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PMID: 29235568
DOI: 10.1038/bjc.2017.363

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