Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.

doi:10.1186/bcr771

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Article

Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.

Breast cancer research : BCR - 1 Jan 2004

Bernstein Jonine L, Langholz Bryan, Haile Robert W, Bernstein Leslie, Thomas Duncan C, Stovall Marilyn, Malone Kathleen E, Lynch Charles F, Olsen Jørgen H, Anton-Culver Hoda, Shore Roy E, Boice John D, Berkowitz Gertrud S, Gatti Richard A, Teitelbaum Susan L, Smith Susan A, Rosenstein Barry S, Børresen-Dale Anne-Lise, Concannon Patrick, Thompson W Douglas

Abstract excerpt

INTRODUCTION: Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks (DSBs) that pose problems for cellular repair processes. Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated. DESIGN: To examine the joint roles of...

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Identifiers

PMID: 15084244
DOI: 10.1186/bcr771
PMCID: PMC400669

Genes

ATM
BRCA1
BRCA2

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