Article
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.
Breast cancer research : BCR - 1 Jan 2004
Bernstein Jonine L, Langholz Bryan, Haile Robert W, Bernstein Leslie, Thomas Duncan C, Stovall Marilyn, Malone Kathleen E, Lynch Charles F, Olsen Jørgen H, Anton-Culver Hoda, Shore Roy E, Boice John D, Berkowitz Gertrud S, Gatti Richard A, Teitelbaum Susan L, Smith Susan A, Rosenstein Barry S, Børresen-Dale Anne-Lise, Concannon Patrick, Thompson W Douglas
Abstract excerpt
INTRODUCTION: Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks (DSBs) that pose problems for cellular repair processes. Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the nor...
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