Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMURF1 Amplification Promotes Invasiveness in Pancreatic Cancer

22 Aug 2011

Abstract excerpt

Pancreatic cancer is a deadly disease, and new therapeutic targets are urgently needed. We previously identified DNA amplification at 7q21-q22 in pancreatic cancer cell lines. Now, by high-resolution genomic profiling of human pancreatic cancer cell lines and human tumors (engrafted in immunodeficient mice to enrich the cancer epithelial fraction), we define a 325 Kb minimal amplicon spanning SMURF1, an E3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21887346
DOI: 10.1371/journal.pone.0023924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMURF1 Amplification Promotes Invasiveness in Pancreatic CancerPMID 21887346Read ↗

Identification of <i>SMURF1</i> as a possible target for 7q21.3‐22.1 amplification detected in a pancreatic cancer cell line by in‐house array‐based comparative genomic hybridizationSemantic proximity Read ↗

Genome‐wide array‐based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcomeSemantic proximity Read ↗

Array-Based Comparative Genomic Hybridization Identifies Localized DNA Amplifications and Homozygous Deletions in Pancreatic CancerSemantic proximity Read ↗

MICAL2 Promotes Pancreatic Cancer Growth and MetastasisSemantic proximity Read ↗

Characterization of the 7q21‐q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancerSemantic proximity Read ↗

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancerSemantic proximity Read ↗

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and MetastasisSemantic proximity Read ↗

Loss of FGFR4 promotes the malignant phenotype of PDAC.Semantic proximity Read ↗

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype.Semantic proximity Read ↗

Genome profiling of pancreatic adenocarcinoma.Semantic proximity Read ↗

HELLS serves as a poor prognostic biomarker and its downregulation reserves the malignant phenotype in pancreatic cancer.Semantic proximity Read ↗

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.