Article
GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo.
PloS one - 1 Jan 2011
Vojnov Lara, Martins Mauricio A, Almeida Jorge R, Ende Zachary, Rakasz Eva G, Reynolds Matthew R, Leon Enrique J, Weisgrau Kim L, Burwitz Benjamin J, Folkvord Joy M, de Santana Marlon G Veloso, Neves Patrícia C Costa, Connick Elizabeth, Skinner Pamela J, Gostick Emma, O'Connor David H, Wilson Nancy A, Bonaldo Myrna C, Galler Ricardo, Price David A, Douek Danny C, Watkins David I
Abstract excerpt
Several lines of evidence suggest that HIV/SIV-specific CD8(+) T cells play a critical role in the control of viral replication. Recently we observed high levels of viremia in Indian rhesus macaques vaccinated with a segment of SIVmac239 Gag (Gag(45-269)) that were subsequently infected with SIVsmE660. These seven Mamu-A*01(+) animals developed CD8(+) T cell responses against an immunodominant epitope in Gag,...
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