Article
High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5α-Restrictive Macaques.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2016
Kannanganat Sunil, Wyatt Linda S, Gangadhara Sailaja, Chamcha Venkatesarlu, Chea Lynette S, Kozlowski Pamela A, LaBranche Celia C, Chennareddi Lakshmi, Lawson Benton, Reddy Pradeep B J, Styles Tiffany M, Vanderford Thomas H, Montefiori David C, Moss Bernard, Robinson Harriet L, Amara Rama Rao
Abstract excerpt
We tested, in rhesus macaques, the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/SIV macaque 239 vaccine. High doses of MVA/GM-CSF did not affect the levels of systemic envelope (Env)-specific Ab, but it did decrease the expression of the gut-homing receptor α4β7 on plasmacytoid...
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