Article
Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.
Human immunology - 1 Nov 2011
Kocián Petr, Šedivcová Monika, Drgáč Jan, Cerná Kateřina, Hoch Jiří, Kodet Roman, Bartůňková Jiřina, Špíšek Radek, Fialová Anna
Abstract excerpt
The prognosis of newly diagnosed colorectal cancer patients relies mostly on tumor-node metastasis classification. However, analyses of tumor-infiltrating lymphocytes and several molecular markers have also shown promising prognostic value. Mutations in the proto-oncogene KRAS, which occur early in colorectal carcinogenesis, have been demonstrated to be common in human colorectal cancer (CRC); however, their...
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