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Article

Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2006

Grady R Mark, Wozniak David F, Ohlemiller Kevin K, Sanes Joshua R

Abstract excerpt

The dystrobrevins (alphaDB and betaDB) bind directly to dystrophin and are components of a transmembrane dystrophin-glycoprotein complex (DGC) that links the cytoskeleton to extracellular proteins in many tissues. We show here that alphaDB, betaDB, and dystrophin are all concentrated at a discrete subset of inhibitory synapses on the somata and dendrites of cerebellar Purkinje cells. Dystrophin is depleted from...

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Share to Dystrophin-Associated Proteins
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Share to Muscular Dystrophy, Animal

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Source

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Identifiers

PMID: 16540561
DOI: 10.1523/JNEUROSCI.4823-05.2006
PMCID: PMC6673965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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