Article
Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1990
De Meyts P, Gu J L, Shymko R M, Kaplan B E, Bell G I, Whittaker J
Abstract excerpt
Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin receptor (INSR) and in insulin dimer formation, suggesting that this domain might also interact with a structure resembling the insulin d...
Topics
- Amino Acid Sequence
- Cells, Cultured
- DNA
- Exons
- Genes
- Humans
- Insulin
- Ligands
- Molecular Sequence Data
- Mutation
- Phenylalanine
- Receptor, Insulin
- Transcription, Genetic
- Transfection