Article
Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1990
De Meyts P, Gu J L, Shymko R M, Kaplan B E, Bell G I, Whittaker J
Abstract excerpt
Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin receptor (INSR) and in insulin dimer formation, suggesting that this domain might also interact with a structure resembling the insulin dimer interface in the INSR. Expression of a mutant INSR cDNA with a deletion of the region corresponding to exon 2 of...
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