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Evaluation of the genotype I Japanese encephalitis virus as a stable viral vector for foreign gene expression.

Antiviral research - 1 Aug 2023

Li Chenxi, Zhang Linjie, Chen Xuan, Jiang Daoyuan, Hu Jingbo, Guo Jinyao, Ding Jingjing, Jiao Xue, Bao Wenbin, Li Yanhua

Abstract excerpt

Manipulation of the flavivirus genome to accommodate and express a heterologous gene of interest has become an attractive approach for gene delivery and the development of viral-vectored vaccines. However, due to the inherent genetic instability of the flavivirus genomes, the construction of recombinant viruses carrying a foreign gene could be problematic and heavily resistant. In this study, the possibility of...

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PMID: 37301446
DOI: 10.1016/j.antiviral.2023.105652

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