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Article

Characterization of a neuraminidase-deficient influenza a virus as a potential gene delivery vector and a live vaccine.

Journal of virology - 1 Mar 2004

Shinya Kyoko, Fujii Yutaka, Ito Hiroshi, Ito Toshihiro, Kawaoka Yoshihiro

Abstract excerpt

We recently identified a packaging signal in the neuraminidase (NA) viral RNA (vRNA) segment of an influenza A virus, allowing us to produce a mutant virus [GFP(NA)-Flu] that lacks most of the NA open reading frame but contains instead the gene encoding green fluorescent protein (GFP). To exploit the expanding knowledge of vRNA packaging signals to establish influenza virus vectors for the expression of foreign...

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Identifiers

PMID: 14990727
DOI: 10.1128/jvi.78.6.3083-3088.2004
PMCID: PMC353727

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Source receipt: pubmed, retrieved 7 Sept 2026.

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