Article
Myosin VI regulates gene pairing and transcriptional pause release in T cells.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015
Zorca Cornelia E, Kim Lark Kyun, Kim Yoon Jung, Krause Matthew R, Zenklusen Daniel, Spilianakis Charalampos G, Flavell Richard A
Abstract excerpt
Naive CD4 T cells differentiate into several effector lineages, which generate a stronger and more rapid response to previously encountered immunological challenges. Although effector function is a key feature of adaptive immunity, the molecular basis of this process is poorly understood. Here, we investigated the spatiotemporal regulation of cytokine gene expression in resting and restimulated effector T helper...
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