Article

ReproTox-KG: Toxicology Knowledge Graph for Structural Birth Defects

2022-09-17

Abstract excerpt

Birth defects are functional and structural abnormalities that impact 1 in 33 births in the United States. Birth defects have been attributed to genetic as well as other factors, but for most birth defects there are no known causes. Small molecule drugs, cosmetics, foods, and environmental pollutants may cause birth defects when the mother is exposed to them during pregnancy. These molecules may interfere with the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae8c7380-90c7-5579-a5e0-d1e0fb3e3999
DOI: 10.1101/2022.09.15.508198

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ReproTox-KG: Toxicology Knowledge Graph for Structural Birth DefectsDOI 10.1101/2022.09.15.508198Read

Toxicology knowledge graph for structural birth defectsSemantic proximity Read

Mapping Chemical-Gene Interactions for Developmental Lethality and Pregnancy LossSemantic proximity Read

Toxicants Associated with Spontaneous Abortion in the Comparative Toxicogenomics Database (CTD)Semantic proximity Read

DEDuCT 3.0: An enhanced and expanded FAIR-compliant resource and toxicology knowledge graph for endocrine disrupting chemicalsSemantic proximity Read

Findings from the National Birth Defects Prevention Study: Interpretation and translation for the clinician.Semantic proximity Read

Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse OutcomesSemantic proximity Read

A curated knowledgebase enabling a network perspective on endocrine disrupting chemicals and their biological systems-level perturbationsSemantic proximity Read

Literature-based predictions of treatments for genetic disease pathologySemantic proximity Read

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening DataSemantic proximity Read

Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS).Semantic proximity Read

BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics dataSemantic proximity Read

FetoML: Interpretable predictions of the fetotoxicity of drugs based on machine learning approachesSemantic proximity Read