Article
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.
Journal of cell science - 1 Sept 2006
Sur Inderpreet, Rozell Björn, Jaks Viljar, Bergström Asa, Toftgård Rune
Abstract excerpt
Krüppel-like factor5 (Klf5) is a zinc-finger transcription factor normally expressed in the skin. Here, we show that overexpression of Klf5 in the basal layer of the epidermis during embryogenesis affects epidermal development and disrupts epithelial-mesenchymal interactions necessary for skin ad...
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