Article
Unexpectedly high frequency of European parentage in Venezuelan patients with chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Feb 2012
Marquez Maria-Elena, Deglesne Pierre-Antoine, Lopez Jose Luis, Da Costa Osiris, Borrego Mildred, Hernández Marcos, Muller Aixa, Ajchenbaum-Cymbalista Florence, Romano Egidio
Abstract excerpt
There is insufficient information on the characteristics of chronic lymphocytic leukemia (CLL) in Latin American patients. Immunoglobulin variable-region heavy-chain (IGVH) gene usage and mutation status and prognostic factors were investigated in patients resident in Venezuela. The most frequently used IGVH family genes were: VH3 > VH1 > VH4 > VH5, with a high incidence of IGVH1.69 and IGVH3.21 genes, and 55.2%...
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