Article
Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Nov 2010
Bianchi Sergio, Moreno Pilar, Landoni Ana Inés, Naya Hugo, Oppezzo Pablo, Dighiero Guillermo, Gabús Raúl, Pritsch Otto
Abstract excerpt
B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of long-lived circulating clonal leukemic B-cells, although the etiopathogenesis remains unclear. The incidence of CLL is variable in different regions around the world. While it is the most frequent chronic leukemia in Western countries, it has a low incidence in Asia. In this work we have investigated the immunoglobulin heavy chain...
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