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Article

Genotype-based quantitative prediction of drug exposure for drugs metabolized by CYP2D6.

Clinical pharmacology and therapeutics - 1 Oct 2011

Tod M, Goutelle S, Gagnieu M C

Abstract excerpt

We propose a framework to enable quantitative prediction of the impact of CYP2D6 polymorphisms on drug exposure. It relies mostly on in vivo data and uses two characteristic parameters: one for the drug and the other for the genotype. The metric of interest is the ratio of drug area under the curve (AUC) in patients with mutant genotype to the AUC in patients with wild-type genotype. Any combination of alleles,...

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PMID: 21866098
DOI: 10.1038/clpt.2011.147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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