Article
Zac1 is an essential transcription factor for cardiac morphogenesis.
Circulation research - 2 Apr 2010
Yuasa Shinsuke, Onizuka Takeshi, Shimoji Kenichiro, Ohno Yohei, Kageyama Toshimi, Yoon Sung Han, Egashira Toru, Seki Tomohisa, Hashimoto Hisayuki, Nishiyama Takahiko, Kaneda Ruri, Murata Mitsushige, Hattori Fumiyuki, Makino Shinji, Sano Motoaki, Ogawa Satoshi, Prall Owen W J, Harvey Richard P, Fukuda Keiichi
Abstract excerpt
RATIONALE: The transcriptional networks guiding heart development remain poorly understood, despite the identification of several essential cardiac transcription factors. OBJECTIVE: To isolate novel cardiac transcription factors, we performed gene chip analysis and found that Zac1, a zinc finger-type transcription factor, was strongly expressed in the developing heart. This study was designed to investigate the...
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