Article
A novel splicing variant of CADM2 as a protective transcript of psoriasis.
Biochemical and biophysical research communications - 9 Sept 2011
Hiruma Azusa, Ikeda Shigaku, Terui Tadashi, Ozawa Maki, Hashimoto Takashi, Yasumoto Shinichiro, Nakayama Juichiro, Kubota Yumiko, Iijima Masafumi, Sueki Hirohiko, Matsumoto Yoshinari, Kato Masayuki, Akasaka Emiko, Ikoma Norihiro, Mabuchi Tomotaka, Tamiya Shiho, Matsuyama Takashi, Ozawa Akira, Inoko Hidetoshi, Oka Akira
Abstract excerpt
CADM2, a candidate gene for psoriasis, was identified by a genome-wide association study using microsatellites in the Japanese population (561 cases and 561 controls). Moreover, haplotype analysis included an additional 68 SNPs and indicated that a 110-kb haplotype block was detected for the protective risk haplotype of psoriasis. We also identified an initial exon of novel splicing variants in this haplotype...
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