Article
Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness.
PloS one - 1 Jan 2011
Rahman Thahira J, Walker Elizabeth A, Mayosi Bongani M, Hall Darroch H, Avery Peter J, Connell John M C, Watkins Hugh, Stewart Paul M, Keavney Bernard
Abstract excerpt
OBJECTIVE: The combined thickness of the intima and media of the carotid artery (carotid intima-medial thickness, CIMT) is associated with cardiovascular disease and stroke. Previous studies indicate that carotid intima-medial thickness is a significantly heritable phenotype, but the responsible genes are largely unknown. Hexose-6 phosphate dehydrogenase (H6PDH) is a microsomal enzyme whose activity regulates...
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