Article
Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia.
The Journal of clinical endocrinology and metabolism - 1 Jan 2007
Smit Pauline, Dekker Marieke J H J, de Jong Frank Jan, van den Beld Annewieke W, Koper Jan W, Pols Huibert A P, Brinkmann Albert O, de Jong Frank H, Breteler Monique M B, Lamberts Steven W J
Abstract excerpt
CONTEXT: Recently, it was proposed that a combination of the 83,557insA polymorphism in the 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene and the R453Q polymorphism in the hexose-6-phosphate dehydrogenase (H6PD) gene interacts to cause cortisone reductase deficiency (CRD) when at least three alleles are affected. OBJECTIVE: The aim was to study the separate and combined effects of these polymorphisms...
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