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Article

Genetic effects on carotid intima-media thickness: systematic assessment and meta-analyses of candidate gene polymorphisms studied in more than 5000 subjects.

Circulation. Cardiovascular genetics - 1 Feb 2010

Paternoster Lavinia, Martinez-Gonzalez Nahara A, Charleton Rebecca, Chung Mabel, Lewis Steff, Sudlow Cathie L M

Abstract excerpt

BACKGROUND: Carotid intima-media thickness (CIMT) is highly heritable and associated with stroke and myocardial infarction, making it a promising quantitative intermediate phenotype for genetic studies of vascular disease. There have been many CIMT candidate gene association studies, but no systematic review to identify consistent, reliable findings. METHODS AND RESULTS: We comprehensively sought all published...

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PMID: 20160191
DOI: 10.1161/CIRCGENETICS.108.834366

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